ANATOMY

Detailed explanation-1: -The glomerulus is a major component of the nephron of the kidneys and plays an important role in blood filtration, removing excessive water and waste product as a form of urine. Glomeruli are the major anatomical sites where many pathological mechanisms of kidney disease occur.

Detailed explanation-2: -The glomerulus filters your blood As blood flows into each nephron, it enters a cluster of tiny blood vessels-the glomerulus. The thin walls of the glomerulus allow smaller molecules, wastes, and fluid-mostly water-to pass into the tubule. Larger molecules, such as proteins and blood cells, stay in the blood vessel.

Detailed explanation-3: -First, the nephrons filter blood that runs through the capillary network in the glomerulus. Almost all solutes, except for proteins, are filtered out into the glomerulus by a process called glomerular filtration. Second, the filtrate is collected in the renal tubules.

Detailed explanation-4: -The process by which glomerular filtration occurs is called renal ultrafiltration. The force of hydrostatic pressure in the glomerulus (the force of pressure exerted from the pressure of the blood vessel itself) is the driving force that pushes filtrate out of the capillaries and into the slits in the nephron.

Detailed explanation-5: -The forces that govern filtration in the glomerular capillaries are the same as any capillary bed. Capillary hydrostatic pressure (Pc) and Bowman’s space oncotic pressure (i) favor filtration into the tubule, and Bowman’s space hydrostatic pressure (Pi) and capillary-oncotic pressure (c) oppose filtration.