ANATOMY

Detailed explanation-1: -The liver and kidneys convert vitamin D (produced in the skin and taken up in the diet), into the active hormone, which is called calcitriol(1, 25-dihydroxyvitamin D).

Detailed explanation-2: -Calcitriol is a hormonally-active, synthetic vitamin D analog prescribed to treat hypocalcemia, osteoporosis, and the prevention of corticosteroid-induced osteoporosis.

Detailed explanation-3: -Calcitriol is used to treat and prevent low levels of calcium and bone disease in patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the amount of calcium in the blood) are not working normally.

Detailed explanation-4: -Calcitriol is an active metabolite of vitamin D with 3 hydroxyl (OH) groups and is commonly referred to as 1, 25-dihydroxycholecalciferol, or 1alpha, 25-dihydroxyvitamin D3, 1, 25-dihydroxyvitamin D3.

Detailed explanation-5: -Circulating calcitriol, a key metabolite in maintaining calcium and phosphorus homeostasis, is produced in the kidney. In kidney failure, calcitriol levels progressively decrease, contributing to the development of renal secondary hyperparathyroidism (SHPT).