ANATOMY

Detailed explanation-1: -Lupus nephritis occurs when lupus autoantibodies affect structures in your kidneys that filter out waste. This causes kidney inflammation and may lead to blood in the urine, protein in the urine, high blood pressure, impaired kidney function or even kidney failure.

Detailed explanation-2: -A person with stage 1 chronic kidney disease (CKD) has kidney damage with a glomerular filtration rate (GFR) at a normal or high level greater than 90 ml/min.

Detailed explanation-3: -Healthy glomeruli keep blood protein (mainly albumin)-which is needed to maintain the right amount of fluid in your body-from seeping into your urine. When damaged, glomeruli allow too much blood protein to leave your body, leading to nephrotic syndrome.

Detailed explanation-4: -Lupus nephritis is inflammation in the kidneys that can make them stop working. When the kidneys aren’t working well, waste builds up in the blood and extra water builds up in the body. Lupus nephritis is most common in people ages 20 to 40. It usually starts within 5 years of your first lupus symptoms.