ANATOMY

Detailed explanation-1: -Renal clearance (ClR) is a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute.

Detailed explanation-2: -By definition, renal clearance is the volume of plasma completely cleared of a substance by the kidneys per unit time. The higher the renal clearance, the more plasma that is cleared of the substance.

Detailed explanation-3: -Renal clearance is used to determine renal elimination mechanisms of a drug, which is the result of glomerular filtration, active tubular secretion and reabsorption. The renal proximal tubule is the primary site of carrier-mediated transport from blood to urine.

Detailed explanation-4: -Clearance is equal to the rate at which a drug is removed from plasma(mg/min) divided by the concentration of that drug in the plasma (mg/mL). The total ability of the body to clear a drug from the plasma is renal clearance plus hepatic clearance plus clearance from all other tissues.

Detailed explanation-5: -Plasma clearance (a volume per time, i.e. a flow) expresses the overall ability of the body to eliminate a drug by scaling the drug elimination rate (amount per time) by the corresponding plasma concentration level.