ANATOMY

Detailed explanation-1: -Gluconeogenesis is the pathway by which glucose is synthesized from non-carbohydrate metabolites. The principal gluconeogenic precursors are pyruvate and lactate, certain gluconeogenic amino acids, and glycerol, which is derived mainly from fat metabolism.

Detailed explanation-2: -Gluconeogenesis is the formation of new glucose molecules in the body as opposed to glucose that is broken down from the long storage molecule glycogen. It takes place mostly in the liver, though it can also happen in smaller amounts in the kidney and small intestine.

Detailed explanation-3: -The major substrates of gluconeogenesis are lactate, glycerol, and glucogenic amino acids.

Detailed explanation-4: -The first step in gluconeogenesis is the conversion of pyruvate to phosphoenolpyruvic acid (PEP). In order to convert pyruvate to PEP there are several steps and several enzymes required. Pyruvate carboxylase, PEP carboxykinase and malate dehydrogenase are the three enzymes responsible for this conversion.