ANATOMY

Detailed explanation-1: -The kidneys grow larger and gradually lose the ability to function as they should. Polycystic kidney disease (PKD) is an inherited disorder in which clusters of cysts develop primarily within your kidneys, causing your kidneys to enlarge and lose function over time. Cysts are noncancerous round sacs containing fluid.

Detailed explanation-2: -Autosomal dominant polycystic kidney disease (ADPKD) is an inherited condition that causes small fluid-filled sacs called cysts to develop in the kidneys.

Detailed explanation-3: -What causes PKD? A gene mutation, or defect, causes PKD. In most PKD cases, a child got the gene mutation from a parent. In a small number of PKD cases, the gene mutation developed on its own, without either parent carrying a copy of the mutated gene.

Detailed explanation-4: -Symptoms usually develop between the ages of 30 and 40, but they can begin during childhood. In this form of the disease, if one of the parents carries the disease gene, the child has a 50/50 chance of inheriting the disease. Autosomal recessive PKD is a rare form.

Detailed explanation-5: -On this page If you have PKD both of your kidneys will be affected but one kidney may develop the cysts earlier than the other. The cysts gradually grow which makes your kidneys larger and reduces the healthy kidney tissue. This makes it harder for your kidneys to work properly.