APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -The coagulation proteins are the core components of the coagulation system that lead to a complex interplay of reactions resulting in the conversion of soluble fibrinogen to insoluble fibrin strands.

Detailed explanation-2: -The coagulation process consists of the conversion of prothrombin to thrombin and of the subsequent action of thrombin on fibrinogen to produce fibrin. In the fibrinogen-fibrin conversion fibrinogen, already a high polymer of many amino acids is converted to an even higher polymeric form or coagulum, the fibrin clot.

Detailed explanation-3: -Thrombin is directly responsible for blood clot formation: it cleaves fibrinogen to yield fibrin monomers which polymerize, and cleaves Protease-Activated Receptor 1 (PAR1) to activate platelets which aggregate [24].

Detailed explanation-4: -Fibrinogen. Fibrinogen is an important soluble plasma clotting factor precursor, which is converted to a threadlike protein called fibrin on contact with a sticky surface.