APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -Impaired chloride transport can cause diseases as diverse as cystic fibrosis, myotonia, epilepsy, hyperekplexia, lysosomal storage disease, deafness, renal salt loss, kidney stones and osteopetrosis.

Detailed explanation-2: -Cystic Fibrosis is a disease affecting mainly secretory organs in humans. The disease is a genetic disorder with malfunctioning CFTR protein. The CFTR protein combines chloride channel properties and ABC transporters and its malfunction results in impaired ion and water transport across the plasma membrane.

Detailed explanation-3: -When the protein is not working correctly, chloride-a component of salt-becomes trapped in cells. Without the proper movement of chloride, water cannot hydrate the cellular surface. This leads the mucus covering the cells to become thick and sticky, causing many of the symptoms associated with cystic fibrosis.