APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -Pepsin is a stomach enzyme that serves to digest proteins found in ingested food. Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen.

Detailed explanation-2: -An enzyme made in the stomach that breaks down proteins in food during digestion. Stomach acid changes a protein called pepsinogen into pepsin.

Detailed explanation-3: -Hydrochloric acid (HCl) converts pepsinogen to pepsin which breaks down proteins into peptides. Hydrochloric acid (HCl) maintains a pH in the stomach of 2.0. It also dissolves food and kills microorganisms.

Detailed explanation-4: -Pepsinogens are synthesized and secreted primarily by the gastric chief cells of the human stomach before being converted into the proteolytic enzyme pepsin, which is crucial for digestive processes in the stomach.

Detailed explanation-5: -Pepsin cleaves peptide bonds in the amino-terminal side of the cyclic amino acid residues (tyrosine, phenylalanine, and tryptophan), breaking the polypeptide chains into smaller peptides (Fange and Grove, 1979).