APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -In small human islets (40–60 m in diameter), -cells had a core position, -cells had a mantle position, and vessels laid at their periphery. In bigger islets, -cells had a similar mantle position but were found also along vessels that penetrate and branch inside the islets.

Detailed explanation-2: -Alpha cells are most commonly found on the dorsal side of the pancreas and are very rarely found on the ventral side of the pancreas. Alpha cells are typically found in compact Islets of Langerhans, which are themselves typically found in the body of the pancreas.

Detailed explanation-3: -The islets of Langerhans, first described by Paul Langerhans in 1869, are dispersed throughout the exocrine tissue of the pancreas. Each islet is an endocrine micro-organ consisting of multiple endocrine cell types, the two most prominent and numerous of which are beta and alpha cells.

Detailed explanation-4: -The islets of Langerhans contain four cell types that each secrete a different peptide: alpha cells secrete glucagon, beta cells secrete insulin, delta cells secrete somatostatin, and P (F) cells secrete pancreatic polypeptide.

Detailed explanation-5: -The normal human pancreas contains about 1 million islets. The islets consist of four distinct cell types, of which three (alpha, beta, and delta cells) produce important hormones; the fourth component (C cells) has no known function.