APPLIED RADIOLOGICAL ANATOMY

ANATOMY

GASTRO INTESTINAL

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which of the following hormones is released by the presence of fat and protein in the small intestine and has major effect to decrease gastric emptying?
A
Cholecystokinin (CCK)
B
Gastrin
C
Glucose Dependent Insulinotorphic Peptide (GIP)
D
Secretin
Explanation: 

Detailed explanation-1: -The presence of fat, such as oleate, in the meal results in stimulation of cholecystokinin (CCK) secretion in the duodenum; in turn, this inhibits antral motility, stimulates pyloric tone and delays gastric emptying [8]. CCK is the first of a repertoire of hormones that regulate gastric emptying.

Detailed explanation-2: -Cholecystokinin is a hormone produced in your small intestine. It plays a fundamental role in the digestive process. When fats and proteins enter your small intestine, cholecystokinin triggers your gallbladder and pancreas to contract.

Detailed explanation-3: -Secretin is secreted from S cells in the duodenum in response to H+ and fatty acids in the lumen. Specifically, a pH less than 4.5 signals arrival of gastric contents, which initiates the release of secretin.

Detailed explanation-4: -Cholecystokinin (CCK) is known to inhibit gastric acid secretion and gastric emptying but its physiological role in the inhibition of gastric functions is not settled.

Detailed explanation-5: -Cholecystokinin is a potent inhibitor of gastric emptying. It is known to both relax the proximal stomach and contract the pyloric sphincter, and either one or both of these actions could mediate inhibition of gastric emptying.

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