APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -Somatostatin is known to inhibit gastric acid secretion via both inhibition of histamine release from gastric enterochromaffin-like cells and direct inhibition of parietal cell function.

Detailed explanation-2: -Somatostatin is a potent inhibitor of gastrin release; its secretion is regulated predominantly by the cholinergic pathway, which inhibits somatostatin and thus stimulates gastrin release. Gastric acid secretion is inhibited by both the paracrine and circulating peptide (hormonal) effects of somatostatin.

Detailed explanation-3: -Gastric delta cells (D-cells), which are somatostatin-secreting cells, are the main paracrine inhibitor of acid secretion.

Detailed explanation-4: -Somatostatin thus lowers gastrin secretion and hydrochloric acid production, while in the small intestines it lowers the secretion of a number of other gastrointestinal hormones, thus inhibiting transit time and bile acid production.

Detailed explanation-5: -Nutrients within the intestine, mainly lipid and protein, release peptide hormones such as cholecystokinin, secretin, neurotensin, and glucagon-like peptide, which may act in concert to inhibit acid secretion.