APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -Pepsin is a stomach enzyme that serves to digest proteins found in ingested food. Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen. Parietal cells within the stomach lining secrete hydrochloric acid that lowers the pH of the stomach. A low pH (1.5 to 2) activates pepsin.

Detailed explanation-2: -The chief cells secrete pepsinogen, a moderately sized zymogen protein with a molecular weight of 40, 400. Pepsin, an enzyme with a molecular weight of 32, 700, is formed in the acidic environment of the stomach when pepsinogen loses its activation peptides.

Detailed explanation-3: -Chief cells release the zymogen (enzyme precursor) pepsinogen when stimulated by a variety of factors including cholinergic activity from the vagus nerve and acidic condition in the stomach. Gastrin and secretin may also act as secretagogues.

Detailed explanation-4: -function in digestive system At the base of the gland are the zymogenic (chief) cells, which are thought to produce the enzymes pepsin and rennin. (Pepsin digests proteins, and rennin curdles milk.)

Detailed explanation-5: -The gastric chief cell (also known as a zymogenic cell or peptic cell) is a cell in the stomach that releases pepsinogen and chymosin. Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with hydrochloric acid produced by gastric parietal cells.