APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -What Causes BSE? Most scientists think that BSE is caused by a protein called a prion. For reasons that are not completely understood, the normal prion protein changes into an abnormal prion protein that is harmful. The body of a sick cow does not even know the abnormal prion is there.

Detailed explanation-2: -According to the protein-only hypothesis, prion diseases are caused by the conformational conversion of the cellular prion protein (PrPC) to its misfolded pathogenic form (PrPSc) (3, 4). Once formed, PrPSc acts as a template to catalyze the conversion of PrPC to PrPSc, resulting in accu-mulation of PrPSc.

Detailed explanation-3: -Abstract. PrPSc (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt–Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer), as well as goat and sheep scrapie.

Detailed explanation-4: -Recent studies highlighted several major roles for PrPc that may be considered in two major domains : (1) cell survival (protection against oxidative stress and apoptosis) and (2) cell adhesion.