APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -Nitric oxide, being a vasodilator, is considered to play a significant role in the homeostatic regulation of renal hemodynamics in both normotensive and hypertensive states [31]. NO mainly produces vasodilation by the eNOS/NO/cGMP pathway.

Detailed explanation-2: -Nitrous oxide added to an isoflurane anesthetic regimen is concluded to be a potent vasodilator. In addition, the vasodilating effects of nitrous oxide were not uniform; they progressively increased with an increasing isoflurane concentration.

Detailed explanation-3: -It relaxes vascular smooth muscle by binding to the heme moiety of cytosolic guanylate cyclase, activating guanylate cyclase and increasing intracellular levels of cyclic-guanosine 3’, 5’-monophosphate, which then leads to vasodilation.

Detailed explanation-4: -The principal mediator of this relaxation has been shown to be nitric oxide (NO) which is released from both autonomic nerves and endothelium (Andersson & Wagner, 1995). Nitic oxide is thought to relax the CSM by activating soluble guanylate cyclase to increase cyclic GMP (cGMP) content (Ignarro et al.