APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -Bilirubin is formed when hemoglobin (the part of red blood cells that carries oxygen) is broken down as part of the normal process of recycling old or damaged red blood cells. Bilirubin is carried in the bloodstream to the liver and is excreted in the bile (the digestive juice produced by the liver).

Detailed explanation-2: -Formation of Bilirubin Roughly, 80% of bilirubin is made from the breakdown of hemoglobin in senescent red blood cells, and prematurely destroyed erythroid cells in the bone marrow. The remainder originates from the turnover of various heme-containing proteins found in other tissues, primarily the liver and muscles.

Detailed explanation-3: -Bilirubin is a yellow bile pigment produced through the breakdown of red blood cells, which is known as haemolysis. Bilirubin is metabolised prior to excretion through the faeces and urine.

Detailed explanation-4: -The heme is then turned into unconjugated bilirubin in the macrophages of the spleen. It is then bound to albumin and sent to the liver. In the liver it is conjugated with glucuronic acid, making it soluble in water. Much of it goes into the bile and thus out into the small intestine.