APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/monocyte lineage that circulate in the blood after their formation in the bone marrow.

Detailed explanation-2: -Osteoclasts resorb bone through the production of proteolytic enzymes and secretion of hydrogen ions into the localized microenvironment under the ruffled border. This extracellular lysosome that is formed beneath the ruffled border results in degradation of collagen and calcified matrix.

Detailed explanation-3: -The osteoclasts are the mediators of the continuous destruction of bone. Osteoclasts occupy small depressions on the bone’s surface, called Howship lacunae; the lacunae are thought to be caused by erosion of the bone by the osteoclasts’ enzymes.

Detailed explanation-4: -Osteoblasts are bone-forming cell, osteoclasts resorb or break down bone, and osteocytes are mature bone cells.

Detailed explanation-5: -Osteoclasts are multinucleated giant cells showing specialized membrane structures, clear zones and ruffled borders, which are responsible for the process of bone resorption.