APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -Currently, intravenous tPA is the only widely available therapy for acute ischemic stroke that has proved to be beneficial. This therapy is effective for reducing neurological disability in selected patients who can be treated within 3 hours of stroke onset.

Detailed explanation-2: -FDA approves tPA for the treatment of acute ischemic stroke.

Detailed explanation-3: -Alteplase (tPA) intravenous thrombolysis is an effective treatment for acute ischemic stroke (AIS) when administered within 4.5 h of initial stroke symptoms.

Detailed explanation-4: -There are strict protocols concerning the appropriate administration of tPA in patients with ischemic stroke, including a list of absolute and relative contraindications. Because of the risk of hemorrhage is thought to outweigh any potential benefits, patients with any absolute contraindication should not be given tPA.

Detailed explanation-5: -Other Contraindications for tPA The National Center for Biotechnology Information lists the following criteria as contraindications for tPA therapy, according to the American Heart Association: Significant head trauma or prior stroke in the previous 3 months. Symptoms suggest subarachnoid hemorrhage.