APPLIED RADIOLOGICAL ANATOMY

Detailed explanation-1: -The definitive diagnosis of Hirschsprung disease is confirmed by a full-thickness rectal biopsy demonstrating the absence of ganglion cells. The specimen must be obtained at least 1.5 cm above the dentate line because aganglionosis may normally be present below this level.

Detailed explanation-2: -Doctors typically use rectal biopsies to confirm or rule out a diagnosis of Hirschsprung disease. During a rectal biopsy procedure, a doctor will take small pieces of tissue from the rectum. A pathologist will examine the tissue under a microscope to look for signs of Hirschsprung disease.

Detailed explanation-3: -Removing a sample of colon tissue for testing (biopsy). This is the surest way to identify Hirschsprung’s disease. A biopsy sample can be collected using a suction device, then examined under a microscope to determine whether nerve cells are missing.

Detailed explanation-4: -Rectal Suction Biopsy (RSB) Data and Efficacy. The median number of RSB specimens per patient sent to the pathologists was three (range one to five). The diagnostic efficacy, defined as sufficient specimens to determine the presence or absence of ganglion cells, of first-time RSB was 85% (71/84) (Table 1).