CHILD DEVELOPMENT PEDAGOGY

Detailed explanation-1: -Acetylation removes positive charges thereby reducing the affinity between histones and DNA. Thus, in most cases, histone acetylation enhances transcription while histone deacetylation represses transcription, but the reverse is seen as well (Reamon-Buettner and Borlak, 2007).

Detailed explanation-2: -Histone acetylation is a critical epigenetic modification that changes chromatin architecture and regulates gene expression by opening or closing the chromatin structure. It plays an essential role in cell cycle progression and differentiation.

Detailed explanation-3: -Methylation of histones can either increase or decrease transcription of genes, depending on which amino acids in the histones are methylated, and how many methyl groups are attached.

Detailed explanation-4: -Acetylation is important for gene regulation. The addition of acetyl groups removes positive charge from the histone molecules, this leads to less interaction between the N terminal of the histone and the phosphate group of the DNA.

Detailed explanation-5: -Indeed, a global increase in core histone acetylation does not necessarily induce widespread transcription[25]. Histone acetylation results in charge neutralization and separation of DNA from the histones allowing nucleosomal DNA to become more accessible to transcription factors.