GROWTH DEVELOPMENT CHILD
GROWTH AND DEVELOPMENT
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
tumor supressor
|
|
|
tumor initiator
|
|
|
stem cell suppressor
|
|
|
stem cell initiator
|
Detailed explanation-1: -The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing and dividing (proliferating) too fast or in an uncontrolled way.
Detailed explanation-2: -(TOO-mer suh-PREH-ser jeen) A type of gene that makes a protein called a tumor suppressor protein that helps control cell growth. Mutations (changes in DNA) in tumor suppressor genes may lead to cancer. Also called antioncogene.
Detailed explanation-3: -Well-described examples of tumor suppressor proteins include RB, p53, APC and CDKN2A/p14 ARF.
Detailed explanation-4: -The cyclin-dependent kinase inhibitor, p21, accomplishes cell cycle arrest by inhibiting cyclin–cdk complexes that phosphorylate cell cycle proteins that mediate the passage from G1 to S (8–10).
Detailed explanation-5: -At the heart of the cell-cycle control system is a family of protein kinases known as cyclin-dependent kinases (Cdks). The activity of these kinases rises and falls as the cell progresses through the cycle.