2018
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
CLP186
|
|
|
CLP257
|
|
|
CLP380
|
|
|
CLP290
|
Detailed explanation-1: -KCC2 is a neuron-specific chloride-extruder that shapes cortical development. Changes in the strength of GABAergic synapses brought about by up-and downregulation of Cl− extrusion by KCC2 exert a major effect on neuronal plasticity and network functions.
Detailed explanation-2: -Potassium-chloride transporter member 5 is also known by the names: KCC2 (potassium chloride cotransporter 2) for its ionic substrates, and SLC12A5 for its genetic origin from the SLC12A5 gene in humans.
Detailed explanation-3: -KCC2 is a glycoprotein of 120 kDa with a predicted structure of 12 transmembrane segments (TMs), six extracellular loops flanked by a short intracellular amino terminal domain (NTD; amino acids 1–103) and a long intracellular carboxy-terminal domain (CTD; last 500 amino acids; Hartmann and Nothwang, 2015; Figure 2).