CURRENT AFFAIRS

Detailed explanation-1: -Pfizer: Following a third dose, children 5 and under elicited a strong immune response, and efficacy was 80.3% in preventing symptomatic infection. These preliminary findings were based on 10 symptomatic cases identified seven days after the third dose.

Detailed explanation-2: -Among children ages 6 through 23 months, the vaccine was 75.8% (2-sided 95% CI: 9.7%, 94.7%) effective at preventing COVID-19, based on 4 cases in the vaccine group (n=296) and 8 cases in the placebo group (n=147), after a median of 1.9 months (range: 0.0, 4.9) follow-up after the third dose.

Detailed explanation-3: -How well it works: When Pfizer-BioNTech applied for FDA authorization for its vaccine in December 2020, its initial Phase 3 clinical data surpassed expectations with 95% efficacy for the prevention of COVID-19, based on an independent analysis by the FDA.

Detailed explanation-4: -Among immunocompromised adults hospitalized with a COVID-like illness, 2-dose monovalent mRNA COVID-19 vaccine VE against COVID-19–associated hospitalization during Omicron predominance was 36%. VE was 67% ≥7 days after a third dose during BA.