DENDROLOGY

Detailed explanation-1: -Pyruvate, which is formed by the glycolytic catabolism of carbohydrates in the cytosol, after it enters mitochondrial matrix undergoes oxidative decarboxylation to form acetyl CoA by a complex set of reactions catalysed by pyruvic dehydrogenase.

Detailed explanation-2: -FORMATION OF CYTOSOLIC PYRUVATE Pyruvate can be created from several sources in the cytosol. A predominant source is from the breakdown of glucose through anaerobic glycolysis into two molecules of pyruvate, ultimately produced by the enzyme pyruvate kinase (Figure 1).

Detailed explanation-3: -In eukaryotic cells, the pyruvate molecules produced at the end of glycolysis are transported into mitochondria.

Detailed explanation-4: -Pyruvate is synthesised in the cytosol by the process of glycolysis. For energy synthesis, pyruvate enters the mitochondria by active transport with the help of pyruvate translocase, a transport protein. Pyruvate is utilised in the citric acid cycle to produce acetyl CoA.