SCIENCE
CELL BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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5
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8
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7
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6
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Detailed explanation-1: -Classically, 7 transmembrane receptors transduce extracellular signals by coupling to heterotrimeric G proteins, although recent in vitro studies have clearly demonstrated that they can also signal via G protein–independent mechanisms.
Detailed explanation-2: -G protein-coupled receptors, or GPCRs, also known as 7-Transmembrane receptors (7-TM receptors), are integral membrane proteins that contain seven membrane-spanning helices.
Detailed explanation-3: -GPCRs are membrane-bound proteins that have seven membrane-spanning domains connected by intracellular and extracellular domains. In the inactive conformation, the a-subunit of the G protein binds to GDP and is bound to a beta-gamma complex (a).
Detailed explanation-4: -A GPCR is made up of a long protein that has three basic regions: an extracellular portion (the N-terminus), an intracellular portion (the C-terminus), and a middle segment containing seven transmembrane domains.