SCIENCE
CELL BIOLOGY
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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False
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True
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Either A or B
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None of the above
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Detailed explanation-1: -The selectins participate exclusively in heterophilic cell-cell binding because they have a lectin-like domain at their NH2 terminus that binds to specific carbohydrate residues on the opposite cell surface (see Figs. 6-1 and 6-2).
Detailed explanation-2: -The selectins are a family of heterophilic CAMs that are dependent on fucosylated carbohydrates, e.g., mucins for binding.
Detailed explanation-3: -The selectins have characteristic extracellular regions composed of an amino-terminal lectin domain that binds a carbohydrate ligand, an epidermal growth factor-like domain, and two to nine short repeat units homologous to domains found in complement binding proteins.
Detailed explanation-4: -The integrins are a family of heterophilic CAMs that bind IgSF CAMs or the extracellular matrix. They are heterodimers, consisting in two non-covalently linked subunits, called alpha and beta.
Detailed explanation-5: -Selectins are carbohydrate-binding transmembrane proteins expressed on platelets (P-selectins), leukocytes (L-selectins) and endothelial cells (E-and P-selectins). Their role is to mediate the first steps of the recruitment of leukocytes from the blood stream in a series of pathologic situations [51].