EVERYDAY SCIENCE

Detailed explanation-1: -According to educational materials provided by the National Institutes of Health [2], monoclonal tumor origin means that tumors are derived from a single ancestral cell that underwent conversion from a normal to a cancerous state.

Detailed explanation-2: -The cells of even the most malignant tumours can be formed from normal tissue cells. The determinants of this abnormal behaviour are to be found in the tumour cells themselves, not in their surroundings(5).

Detailed explanation-3: -Monoclonality refers to the state of a line of cells that have been derived from a single clonal origin. Thus “monoclonal cells” can be said to form a single clone. The term monoclonal comes from the Ancient Greek monos, meaning “alone” or “single", and klon, meaning “twig".

Detailed explanation-4: -a monoclonal tumor. especially : relating to or being an antibody derived from a single cell in large quantities for use against a specific antigen (as a cancer cell)