EVERYDAY SCIENCE

Detailed explanation-1: -The ubiquitin protein itself consists of 76 amino acids and has a molecular mass of about 8.6 kDa. Key features include its C-terminal tail and the 7 lysine residues. It is highly conserved throughout eukaryote evolution; human and yeast ubiquitin share 96% sequence identity.

Detailed explanation-2: -Ubiquitin is a 76-amino acid protein, and as such bears many potential sites for additional post-translational modifications. The key features of ubiquitin are its seven Lys residues, all of which can be ubiquitinated, to give rise to isopeptide-linked ubiquitin chains.

Detailed explanation-3: -Ubiquitin is a 76-amino-acid polypeptide, and ubiquitylation occurs via formation of an isopeptide bond between an internal lysine of the substrate and the C-terminal glycine (glycine 76) of ubiquitin.

Detailed explanation-4: -Explanation: Ubiquitin is a 76 amino acid polypeptide. This is highly conserved in all eukaryotes (yeasts, animals and plants).

Detailed explanation-5: -The 76-amino acid protein ubiquitin is attached covalently to other proteins to in turn, modify or expand their cellular activities. The most common sites of ubiquitin attachment are Lys epsilon-amino groups and the substrate’s amino terminus, as reviewed in (1).