EVERYDAY SCIENCE

Detailed explanation-1: -Clathrin plays a major role in formation of clathrin-coated pits and coated vesicles.

Detailed explanation-2: -Clathrin-coated vesicles have been implicated in several distinct intracellular transport steps. In particular, the internalisation of plasma membrane proteins by receptor-mediated endocytosis (RME) and the transport of lysosomal enzymes from the TGN [2-4].

Detailed explanation-3: -Receptor-mediated endocytosis (RME), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, proteins – and in some cases viruses – by the inward budding of the plasma membrane (invagination).

Detailed explanation-4: -Receptor-mediated endocytosis is a form of endocytosis in which receptor proteins on the cell surface are used to capture a specific target molecule. The receptors, which are transmembrane proteins, cluster in regions of the plasma membrane known as coated pits.

Detailed explanation-5: -Clathrin-coated vesicles bud from the plasma membrane and from the trans-Golgi network; both populations of coated vesicles participate in the endocytic pathway.