EVERYDAY SCIENCE

Detailed explanation-1: -If a method’s sensitivity, k, is too dependent on experimental conditions, such as temperature, acidity, or reaction time, then a slight change in any of these conditions may give a significantly different result. A rugged method is relatively insensitive to changes in experimental conditions.

Detailed explanation-2: -Ruggedness testing is carried out as part of a precision study and the goal is to establish the effect of small changes in the method conditions (such as temperature or instrumental settings) on the qualitative and quantitative abilities of the method.

Detailed explanation-3: -The terms robustness and ruggedness refer to the ability of an analytical method to remain unaffected by small variations in the method parameters (mobile phase composition, column age, column temperature, etc.) and influential environmental factors (room temperature, air humidity, etc.)

Detailed explanation-4: -Ruggedness is normally expressed as the lack of influence on the test results of operational and environmental variables of the analytical method. Ruggedness is a measure of reproducibility of test results under the variation in conditions normally expected from laboratory to laboratory & from analyst to analyst.

Detailed explanation-5: -Ruggedness is a measure of reproducibility of test results under the variation in conditions normally expected from laboratory to laboratory and analyst to analyst.” This definition clearly refers to inter-laboratory studies.