EVERYDAY SCIENCE

Detailed explanation-1: -A type of immune cell that is made in the bone marrow and travels through the blood to tissues in the body where it becomes a macrophage or a dendritic cell.

Detailed explanation-2: -Monocytes can differentiate into inflammatory or anti-inflammatory subsets. Upon tissue damage or infection, monocytes are rapidly recruited to the tissue, where they can differentiate into tissue macrophages or dendritic cells.

Detailed explanation-3: -The spleen has been considered to be an immediate reservoir of monocytes that mobilizes a large quantity of monocytes upon injury. Several studies reported the involvement of the spleen in inflammatory diseases.

Detailed explanation-4: -Monocytes are produced by the bone marrow from precursors called monoblasts, bipotent cells that differentiated from hematopoietic stem cells.