EVERYDAY SCIENCE

Detailed explanation-1: -Definition. An oncogene is a mutated gene that has the potential to cause cancer. Before an oncogene becomes mutated, it is called a proto-oncogene, and it plays a role in regulating normal cell division.

Detailed explanation-2: -(ON-koh-jeen) A mutated (changed) form of a type of gene called a proto-oncogene, which is involved in normal cell growth and division. When a proto-oncogene is changed so that too many copies are made or it becomes more active than normal, it is called an oncogene.

Detailed explanation-3: -Three closely related members of the ras gene family (rasH, rasK, and rasN) are the oncogenes most frequently encountered in human tumors. These genes are involved in approximately 20% of all human malignancies, including about 50% of colon and 25% of lung carcinomas.

Detailed explanation-4: -The most commonly mutated gene in people with cancer is p53 or TP53. More than 50% of cancers involve a missing or damaged p53 gene. Most p53 gene mutations are acquired. Germline p53 mutations are rare, but patients who carry them are at a higher risk of developing many different types of cancer.

Detailed explanation-5: -An oncogene is a gene that when mutated or expressed at abnormally high levels contribute to converting a normal cell into a cancer cell. Cancer cells are cells that are engaged in uncontrolled mitosis. Video Explanation.