EVERYDAY SCIENCE

Detailed explanation-1: -Almost 40% of lactate in the circulation is released from the skeletal muscle. This lactate is further absorbed mostly by the liver and kidney, where it undergoes oxidation for the synthesis of glucose.

Detailed explanation-2: -Lactate is mainly metabolized by the liver (around 60%) and kidney (around 30%) [6], and the rate of lactate clearance in the normal liver exceeds the rate of lactate production of other tissues [8].

Detailed explanation-3: -The contribution of the liver to the development of lactic acidosis was found to be variable. When hepatic oxygen consumption was decreased, the liver was documented as the major site of lactate production with an associated increase in the lactate-pyruvate ratio of hepatic venous blood.

Detailed explanation-4: -Lactate is metabolized primarily by the liver [16-18]. Though previous studies have suggested that liver dysfunction is associated with higher lactate levels in the acutely ill [15, 19, 20], the impact of liver disease (LD) on the early stages of an acute resuscitation in sepsis is not well-known.

Detailed explanation-5: -Your liver and kidneys filter lactic acid out of your blood and break it down into glucose (blood sugar).