EVERYDAY SCIENCE

Detailed explanation-1: -The perichondrium is important for the functioning of the cartilage tissue because of its role in wound healing and regeneration, and the hypothesized function of metabolic regulation, which prevents cartilage calcification.

Detailed explanation-2: -Taken together, articular chondrocytes and the extracellular matrix participate in cartilage injury. The first task for the repair and regeneration of cartilage is chondrocyte activation and the release of cells from their locations in the matrix. This is achieved mainly by the release of ADAMTS-5 and MMP-13.

Detailed explanation-3: -The perichondrium consists of an outer fibrous layer that contains fibroblasts and an inner chondrogenic layer that contains chondroblasts. The main functions of the perichondrium are to protect bones from injury and damage, nourish cartilage through blood vessels, and facilitate cartilage growth.

Detailed explanation-4: -The surface of most cartilage is covered by a layer of dense irregular connective tissue called the perichondrium (peri = around). The outer layer of the perichondrium contains collagen producing fibroblasts, and the inner layer contains chondroblasts.

Detailed explanation-5: -The regeneration of cartilage can occur from its perichondrium as it contains mesenchymal cell like features which are the progenitor cells. This enables it to undergo chondrogenesis and hence can help in cartilage regeneration at the site of defective tissue.