LIFE SCIENCE

OBJECTIVE LIFE SCIENCE

BIOCHEMISTRY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Allosteric activators
A
bind via covalent attachment.
B
stabilize conformations with higher Ks.
C
stabilize conformations with higher substrate affinity.
D
all of the above
E
none of the above
Explanation: 

Detailed explanation-1: -Allosteric Enzymes are regulated by other molecules. This is seen when the molecules 2, 3-BPG, pH, and CO2 modulates the binding affinity of hemoglobin to oxygen. 2, 3-BPG reduces binding affinity of O2 to hemoglobin by stabilizing the T-state.

Detailed explanation-2: -Allosteric activation and inhibition Depends on which state of the enzyme, regulators can be used to stabilize the enzyme’s conformation; the binding of an activator at regulator site can stabilize the active form of that allosteric enzyme while the binding of an inhibitor stabilizes the inactive form of the enzyme.

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