LIFE SCIENCE

Detailed explanation-1: -A drastic change in temperature, pH or chemical environment or chemical solution, denatures enzymes. Denatured enzymes are not in their natural form and no longer have a functional active site. They may completely lose their conformation and subsequent ability to catalyze reactions.

Detailed explanation-2: -Answer and Explanation: A denatured enzyme is incapable of providing its necessary function as it cannot actually perform its catalytic function. Denatured enzymes are unable to perform their functions as their ligands (keys) cannot bind to their active sites (locks), and thus no catalysis can actually be performed.

Detailed explanation-3: -Why does denaturation prevent an enzyme from being able to catalyze its reaction? 1. denaturation changes the shape of the enzyme’s active site so that it cannot bind correctly with its substrate.

Detailed explanation-4: -Enzyme structures unfold (denature) when heated or exposed to chemical denaturants and this disruption to the structure typically causes a loss of activity. Protein folding is key to whether a globular protein or a membrane protein can do its job correctly.

Detailed explanation-5: -The rate of an enzyme-catalyzed reaction increases with an increase in the concentration of an enzyme. At low temperatures, an increase in temperature increases the rate of an enzyme-catalyzed reaction. At higher temperatures, the protein is denatured, and the rate of the reaction dramatically decreases.