LIFE SCIENCE

Detailed explanation-1: -Ans. 4. (E) Pro, Gly The most conformationally restricted amino acid is Proline because of its rigid structure an…

Detailed explanation-2: -"The -amino acids, molecules of which have restricted conformational flexibility, are widely used in design of peptidomimetics, peptide models, and in systematic search for biologically active compounds.

Detailed explanation-3: -The distinctive cyclic structure of proline’s side chain gives proline an exceptional conformational rigidity compared to other amino acids. It also affects the rate of peptide bond formation between proline and other amino acids.

Detailed explanation-4: -Glycine and ala-nine are two small hydrophobic amino acids as the most flexible molecules in proteins.

Detailed explanation-5: -Proline is unique among the naturally-occurring amino acids in that the side-chain wraps around to form a covalent bond with the backbone, severely restricting the backbone.