LIFE SCIENCE

Detailed explanation-1: -Vamorolone Stabilizes Dysferlin-Deficient Cell Membrane by Reducing Lipid Mobility. Lipophilic molecules, such as steroidal drugs, can affect membrane rigidity as well as lateral diffusion of proteins and lipids in the plasma membranes.

Detailed explanation-2: -One of cholesterol’s functions is to reduce the fluidity of the membrane.To do so, it forms strong interactions with phospholipids using its rigid steroid ring structure. At high temperatures, these interactions stiffen the membrane and interfere with phospholipid mobility.

Detailed explanation-3: -Cholesterol is the most common steroid in the body. It is a precursor to vitamin D and many steroid hormones, including testosterone, estrogen, and cortisol. Cholesterol belongs in the family of steroids because it shares a similar chemical structure.

Detailed explanation-4: -Acting as essential building blocks of the plasma membranes, cholesterol plays pivotal roles in maintaining the structural integrity and regulating the fluidity of cell membranes [17–20], therefore contributing to the homeodynamics of various membrane proteins on the cell surface.