LIFE SCIENCE

OBJECTIVE LIFE SCIENCE

BIOCHEMISTRY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The enzyme fumarase catalyzes the reversible hydration of fumaric acid to l-malate, but it will not catalyze the hydration of maleic acid, the cis isomer of fumaric acid. This is an example of:
A
biological activity.
B
chiral activity.
C
racemization.
D
stereoisomerization.
E
stereospecificity.
Explanation: 

Detailed explanation-1: -The enzyme fumarase catalyzes the reversible hydration of fumaric acid to l-malate, but it will not catalyze the hydration of maleic acid, the cis isomer of fumaric acid. This is an example of: A. biological activity.

Detailed explanation-2: -This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (S)-malate hydro-lyase (fumarate-forming). Other names in common use include: fumarase.

Detailed explanation-3: -Answer and Explanation: The enzyme responsible for the conversion of fumarate to malate is fumarase, or fumarate hydratase. The enzyme catalyzes the reversible process of fumarate to malate via hydration/dehydration reactions.

Detailed explanation-4: -In eukaryotes, fumarase (FH in human) is a well-known tricarboxylic-acid-cycle enzyme in the mitochondrial matrix.

Detailed explanation-5: -Fumarase catalyzes the reversible conversion of fumarate to S-malate during the operation of the ubiquitous Kreb’s cycle.

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