LIFE SCIENCE

Detailed explanation-1: -Glucose 6-phosphate is dephosphorylated by glucose 6-phosphatase to form glucose, which is free to enter the bloodstream. This reaction is unique to gluconeogenesis and bypasses the irreversible reaction catalyzed by the glycolytic enzyme hexokinase.

Detailed explanation-2: -Glucose-6-phosphatase is a microsomal enzyme responsible for catalyzing the conversion of glucose-6-phosphate to glucose.

Detailed explanation-3: -Gluconeogenesis is the synthesis of glucose from nonsugar sources, especially amino acids and TCA cycle intermediates. Running glycolysis in the synthetic direction requires that there be a way to bypass the three free energy drops in the pathway, that is, the pyruvate kinase, phosphofructokinase, and hexokinase steps.

Detailed explanation-4: -Abstract. The classical role of glucose-6-phosphatase in liver and kidney is the production of glucose for release into blood. In liver, glucose-6-phosphatase catalyses the terminal step of glycogenolysis and gluconeogenesis.

Detailed explanation-5: -The enzyme glucose 6-phosphatase (EC 3.1. 3.9, G6Pase; systematic name D-glucose-6-phosphate phosphohydrolase) catalyzes the hydrolysis of glucose 6-phosphate, resulting in the creation of a phosphate group and free glucose: Glucose 6-phosphatase.