LIFE SCIENCE

OBJECTIVE LIFE SCIENCE

BIOCHEMISTRY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What is the first enzyme that transforms glucose to glucose-6-phosphate (G6P)?
A
Hexokinase (HK)
B
Triose phosphate isomerase (TIM)
C
Phosphoglycerate kinase (PGK)
D
Phosphofructokinase (PFK)
Explanation: 

Detailed explanation-1: -Hexokinase (EC 2.7. 1.1) catalyzes the formation of glucose 6-phosphate (G6P) from glucose.

Detailed explanation-2: -From glucose Within a cell, glucose 6-phosphate is produced by phosphorylation of glucose on the sixth carbon. This is catalyzed by the enzyme hexokinase in most cells, and, in higher animals, glucokinase in certain cells, most notably liver cells.

Detailed explanation-3: -Metabolic Pathways in the Human Body Glucose-6-phosphate (G6P) is changed into fructose-6-phosphate (F6P) by phosphoglucoisomerase (phosphoglucose isomerase) in the second step.

Detailed explanation-4: -Hexokinase is the first enzyme in the glycolytic pathway, and it converts glucose into glucose-6-phosphate. It uses ATP to phosphorylate the 6-hydroxyl group of glucose, and it is inhibited by its product, glucose-6-phosphate. It is also allosterically relieved of product inhibition by phosphate.

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