LIFE SCIENCE

Detailed explanation-1: -When an enzyme is denatured, it loses it native conformation, or three-dimensional structure. A denatured enzyme is unable to bind to its substrate and increase the chemical rate of reaction.

Detailed explanation-2: -Enzymes work consistently until they are dissolved, or become denatured. When enzymes denature, they are no longer active and cannot function. Extreme temperature and the wrong levels of pH–a measure of a substance’s acidity or alkalinity–can cause enzymes to become denatured.

Detailed explanation-3: -Factors affecting enzyme activity Temperature: Raising temperature generally speeds up a reaction, and lowering temperature slows down a reaction. However, extreme high temperatures can cause an enzyme to lose its shape (denature) and stop working.

Detailed explanation-4: -Since a protein’s function is dependent on its shape, a denatured protein is no longer functional.

Detailed explanation-5: -Denaturation is a process in which proteins lose their shape and, therefore, their function because of changes in pH or temperature.