LIFE SCIENCE

Detailed explanation-1: -Denaturation of enzymes causes bonds to be broken, structure to be disrupted and it stops functioning. This happens to enzymes when they are exposed to extreme, unsuitable conditions, for instance, high temperatures or extreme pH levels.

Detailed explanation-2: -When an enzyme denatures, its active site changes its shape, as you can see in this diagram. This is because the protein structure of the enzyme has changed. You might notice that the active site is no longer a complementary shape to a specific substrate molecule.

Detailed explanation-3: -Because enzyme function is dependent upon the ability of an enzyme to bind to its substrate, the loss of an enzyme’s three-dimensional structure as a result of denaturation renders the enzyme ineffective.

Detailed explanation-4: -When the shape of an enzyme (and more specifically its active site) changes, it is no longer able to bind to its substrate. The enzyme is deactivated and no longer has an effect on the rate of the reaction. Enzymes can also be deactivated by other molecules.