LIFE SCIENCE

OBJECTIVE LIFE SCIENCE

CELL BIOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
On a human karyotype, what chromosome pair would have a mutation when there is a diagnosis of Klinefelter’s Syndrome?
A
The first pair of chromosomes
B
The second pair of chromosomes
C
The 21st pair of chromosomes
D
The 23rd pair of chromosomes
Explanation: 

Detailed explanation-1: -There are 2 types of chromosome, called the sex chromosomes, that determine the genetic sex of a baby. These are named either X or Y. Usually, a female baby has 2 X chromosomes (XX) and a male has 1 X and 1 Y (XY). But in Klinefelter syndrome, a boy is born with an extra copy of the X chromosome (XXY).

Detailed explanation-2: -23 duplication syndrome is a condition that can cause a variety of neurological and behavioral problems as well as other abnormalities. People with 7q11. 23 duplication syndrome typically have delayed development of speech and motor skills such as crawling and walking.

Detailed explanation-3: -The genotype of a person having Klinefelter syndrome is 44+XXY. It is caused due to the presence of an additional copy of X-chromosomes resulting in 44+XXY type chromosome complement. The defect appears due to an abnormal egg (22+XX) and a normal (22+X) and abnormal sperm (22+XY).

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