LIFE SCIENCE

Detailed explanation-1: -For myeloid tumors, monoclonal tumor origin may be the predominant path to cancer and a monoclonal tumor origin cannot be ruled out for a fraction of other cancer types. Nevertheless, a large body of evidence supports the conclusion that most cancers are multiclonal in origin.

Detailed explanation-2: -Monoclonal tumor origin refers to the idea that all cells within a tumor can be traced back to a single progenitor cell (Fig. 1A). The monoclonal origin of cancer is commonly accepted as fact.

Detailed explanation-3: -A significant indication of the monoclonal origin of tumors is that a tumor is considered to be like a clone of a mutated cell; however, the frequency of tumor formation is so low, compared with the expected frequency of mutation, that the existence of a mechanism to suppress tumor formation should be considered.