LIFE SCIENCE

Detailed explanation-1: -In sickle cell anemia (also called homozygous sickle cell disease), which is the most common form of sickle cell disease, hemoglobin S replaces both beta-globin subunits in hemoglobin. In other types of sickle cell disease, just one beta-globin subunit in hemoglobin is replaced with hemoglobin S.

Detailed explanation-2: -The valine-type hemoglobin causes red cells to sickle when exposed to a low oxygen threshold. Patient with sickle cell trait inherits HbS from one parent and HbA from the other parent making them heterozygous.

Detailed explanation-3: -Sickle cell anemia (SCA) is characterized by the homozygosity for hemoglobin S (HbS) and is the most frequent and severe form of the disease. The point mutation of GAG to GTG in the sixth codon of the (beta) globin gene (HBB), which replaces the glutamic acid for a valine, leading to HbS formation [2].

Detailed explanation-4: -Sickle cell disease, which is also called SS genotype, is an inherited form of anemia – a condition in which there aren’t enough healthy red blood cells to carry adequate oxygen throughout the body, says Dr.