LIFE SCIENCE

Detailed explanation-1: -Missense: A missense variant is a type of substitution in which the nucleotide change results in the replacement of one protein building block (amino acid) with another in the protein made from the gene. The amino acid change may alter the function of the protein.

Detailed explanation-2: -In genetics, a missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid. It is a type of nonsynonymous substitution.

Detailed explanation-3: -A missense mutation is a mistake in the DNA that results in the integration of an undesirable amino acid into a protein as a result of changing a single nucleotide in the DNA. The finest example of a missense alteration is a pallor known as sickle cell anaemia.