OBJECTIVE LIFE SCIENCE
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Replication will occur via RNA polymerase alone.
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The DNA will supercoil.
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No replication fork will be formed.
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No proofreading will occur.
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Detailed explanation-1: -coli, there is a mutation in a gene called dnaB that alters the helicase that normally acts at the origin of replication. Which of the following would you expect as a result of this mutation? O No replication fork will be formed and there will be no DNA replication.
Detailed explanation-2: -High accuracy (fidelity) of DNA replication is important for cells to preserve genetic identity and to prevent accumulation of deleterious mutations.
Detailed explanation-3: -DnaC helicase loader (DnaC) transfers helicase to replication origins. The helicase loaders belong to two classes. The ‘ring breakers’ break the hexameric helicase to allow the DNA to pass through. The ‘ring makers’ assemble the helicase monomers to hexamers around the DNA.