OBJECTIVE LIFE SCIENCE
MOLECULAR BIOLOGY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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the two DNA strands have completely separated and exposed the promoter.
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several transcription factors have bound to the promoter.
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the 5’ caps are removed from the mRNA.
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the DNA introns are removed from the template.
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Detailed explanation-1: -Eukaryotic transcription begins when the transcription factors bind to the exposed promoter. The transcription factors then bind the appropriate RNA polymerase to the complex to initiate transcription. Thus, transcription factors must bind to the promoter to initiate eukaryotic transcription.
Detailed explanation-2: -During transcription, the TATA-binding protein (TBP) of the transcription factor IID (TFIID) multisubunit complex binds this sequence and bends the DNA to commence recruitment of the transcription machinery. TATA-containing promoters make up only 10–15% of the mammalian promoters.
Detailed explanation-3: -A promoter, as related to genomics, is a region of DNA upstream of a gene where relevant proteins (such as RNA polymerase and transcription factors) bind to initiate transcription of that gene. The resulting transcription produces an RNA molecule (such as mRNA).