LIFE SCIENCE

OBJECTIVE LIFE SCIENCE

MOLECULAR BIOLOGY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Origin of replication in bacteria usually contains
A
GC rich sequence
B
Both AT and GC rich sequence
C
No particular stretch of sequence
D
AT rich sequence
Explanation: 

Detailed explanation-1: -The AT-rich regions in bacterial chromosomal origins of replication are usually located on one side of a cluster of DnaA-box sequences. In case of the plasmid origins, this rule applies to the AT-rich region and the iteron sequences recognized by initiator proteins.

Detailed explanation-2: -Bacterial replication origins carry DNA sequence motifs recognized by DnaA and other proteins, and an AT-rich region named the DNA unwinding element (DUE). Among bacteria however, the presence, relative arrangement, and position of these DNA motifs are not conserved.

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